Géraudie J, Ferretti P
Laboratoire de Biologie du Développement, Université Paris, France.
Int Rev Cytol. 1998;180:1-50. doi: 10.1016/s0074-7696(08)61769-6.
Limb regeneration in adult urodeles is an important phenomenon that poses fundamental questions both in biology and in medicine. In this review, we focus on recent advances in the characterization of the regeneration blastema at cellular and molecular levels and on the current understanding of the molecular basis of limb regeneration and its relationship to development. In particular, we discuss (i) the spatiotemporal distribution of genes and gene products in the mesenchyme and wound epidermis of the regenerating limb, (ii) how growth is controlled in the regeneration blastema, and (iii) molecules that are likely to be involved in patterning the regenerating limb such as homeobox genes and retinoids.
成年有尾两栖类动物的肢体再生是一个重要现象，它在生物学和医学领域都引发了一些基本问题。在这篇综述中，我们重点关注了再生芽基在细胞和分子水平上的特征研究的最新进展，以及目前对肢体再生分子基础及其与发育关系的理解。特别地，我们讨论了：（i）再生肢体的间充质和伤口表皮中基因及基因产物的时空分布；（ii）再生芽基中生长是如何被调控的；（iii）可能参与再生肢体模式形成的分子，如同源框基因和类视黄醇。
