Murri L, Galli R
Institute of Neurology, University of Pisa, Italy.
Cephalalgia. 1997 Dec;17 Suppl 20:46-7. doi: 10.1177/0333102497017S2014.
This study was undertaken to determine plasma allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one, A-PREG) and pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one, PREG) concentrations in the luteal phase (22nd to 24th day of the ovarian cycle) in 15 women with partial epilepsy and catamenial exacerbation of the seizures in the intercritical phase and in 15 healthy women matched for age in order to determine if an impaired metabolism of 3alpha-hydroxymetabolites of progesterone (P) occurs in this convulsive disorder. No significant differences between the two groups were found with respect to the mean plasmatic A-PREG and PREG levels. A significant correlation was found instead between P and A-PREG or PREG concentrations.
本研究旨在测定15名部分性癫痫且发作有月经周期发作加重的女性在黄体期（卵巢周期第22至24天）以及15名年龄匹配的健康女性在黄体期的血浆别孕烷醇酮（3α-羟基-5α-孕烷-20-酮，A-PREG）和孕烷醇酮（3α-羟基-5β-孕烷-20-酮，PREG）浓度，以确定在这种惊厥性疾病中孕酮（P）的3α-羟基代谢产物的代谢是否受损。两组之间在血浆A-PREG和PREG平均水平方面未发现显著差异。相反，发现P与A-PREG或PREG浓度之间存在显著相关性。
