Müller F, Aukrust P, Lien E, Haug C J, Frøland S S
Medical Department A, University of Oslo, and Rikshospitalet, Norway.
J Infect Dis. 1998 Mar;177(3):586-94. doi: 10.1086/514222.
Patients with advanced human immunodeficiency virus (HIV) infection are susceptible to infections with Mycobacterium avium complex (MAC). Interleukin (IL)-10 may impair immunity to MAC; therefore, the effect of different MAC preparations on IL-10 production was examined in mononuclear cell cultures from HIV-infected patients. IL-10 levels in cultures for 26 patients were higher than those in 20 control cultures. The highest IL-10 levels were found in cultures from patients with the most advanced HIV disease. Monocytes were the major IL-10 producers, while little IL-10 could be attributed to Th2 lymphocytes. Cultures for patients produced reduced levels of tumor necrosis factor-alpha and normal levels of IL-12; the production of these cytokines increased after neutralization of IL-10. Circulating IL-10 was higher in HIV-infected patients than in controls, with the highest levels in the AIDS group. Elevated monocyte/macrophage-derived IL-10 production may contribute to the high susceptibility to MAC infection seen in patients with advanced HIV disease.
晚期人类免疫缺陷病毒（HIV）感染患者易感染鸟分枝杆菌复合体（MAC）。白细胞介素（IL）-10可能会损害对MAC的免疫力；因此，在来自HIV感染患者的单核细胞培养物中检测了不同MAC制剂对IL-10产生的影响。26例患者培养物中的IL-10水平高于20例对照培养物中的水平。在HIV疾病最严重的患者培养物中发现了最高的IL-10水平。单核细胞是主要的IL-10产生者，而很少有IL-10可归因于Th2淋巴细胞。患者的培养物中肿瘤坏死因子-α水平降低，IL-12水平正常；在中和IL-10后，这些细胞因子的产生增加。HIV感染患者循环中的IL-10高于对照组，艾滋病组中水平最高。单核细胞/巨噬细胞衍生的IL-10产生升高可能导致晚期HIV疾病患者对MAC感染的高度易感性。
