Novak R M, Koirala J, Sirdar M L, D'Alfonso-Laghi N, Moreira L, Pitrak D L, Ghassemi M
University of Illinois, Chicago 60612, USA.
J Clin Immunol. 2000 Jan;20(1):62-7. doi: 10.1023/a:1006646711977.
Published reports have demonstrated that antigens of Mycobacterium avium complex (MAC) can suppress the normal response to mitogens in lymphoproliferation assays. We therefore studied the lymphoproliferative (LP) function of PBMC from 55 HIV-infected patients and 16 controls in response to mitogens with and without MAC antigen. As expected, LP responses decline with progressive decline in CD4 count; MAC antigen in combination with PHA further suppresses that response in a dose-dependent manner. More relevant were the LP responses in those with CD4 counts less than 100. All patients with MAC disease had poor responses (stimulation index, SI < 10) to PHA or anti-CD3 with or without MAC antigen. Those who did not have nor subsequently developed MAC were both good (SI > 10) or poor responders (SI < 10). The suppressive effect of MAC on lymphocyte function may serve as a weak virulence factor which is only relevant in severely immunocompromised HIV patients.
已发表的报告表明，鸟分枝杆菌复合体（MAC）的抗原在淋巴细胞增殖试验中可抑制对有丝分裂原的正常反应。因此，我们研究了55例HIV感染患者和16例对照的外周血单个核细胞（PBMC）在有或无MAC抗原存在时对有丝分裂原的淋巴细胞增殖（LP）功能。正如预期的那样，LP反应随着CD4计数的逐渐下降而降低；MAC抗原与PHA联合使用会以剂量依赖的方式进一步抑制该反应。更相关的是CD4计数低于100的患者的LP反应。所有患有MAC疾病的患者对PHA或抗CD3（无论有无MAC抗原）的反应均较差（刺激指数，SI<10）。那些既没有患MAC疾病也没有随后发展为MAC疾病的患者，反应良好（SI>10）或较差（SI<10）。MAC对淋巴细胞功能的抑制作用可能是一种弱毒力因子，仅在严重免疫受损的HIV患者中起作用。
