Hall A B, Thompson J R, Deane J S, Rosenthal A R
Department of Ophthalmology, University of Leicester, England, U.K.
Ophthalmic Epidemiol. 1997 Dec;4(4):179-94. doi: 10.3109/09286589709059192.
To compare two methods of cataract grading for nuclear cataract, cortical cataract and posterior subcapsular cataract.
The Melton Eye Study is an English community-based epidemiological study of the natural history of eye disease in people aged 55 to 74 years. The lenses of both eyes of 560 subjects were graded at the slit lamp using two cataract grading systems. The Oxford Clinical Cataract Classification and Grading System (OCCCGS) employs standard diagrams and Munsell colour samples for the grading of cortical, posterior subcapsular and nuclear cataract. The Lens Opacities Classification System III (LOCS III) uses photographic transparencies of the lens as standards. In both systems a decimalised score is assigned. We also graded the LOCS III standard images using the OCCCGS. Interobserver variation was calculated for both grading systems. Linear calibration lines are plotted for each type of lens opacity.
The relationship between LOCS III and OCCCGS for nuclear cataract and posterior subcapsular cataract is linear. The relationship for cortical cataract is linear once the LOCS III scores are squared. The intervals between the LOCS III images when ranked by the human eye using the OCCCGS are linear. Interobserver variation for both systems is good.
The linear calibration lines may be used to convert from one system to another and will be useful in comparing studies or performing meta-analysis. These results show that data from cataract studies using different clinical grading schemes can be compared.
比较两种用于核性白内障、皮质性白内障和后囊下白内障分级的方法。
梅尔顿眼研究是一项基于英国社区的关于55至74岁人群眼部疾病自然史的流行病学研究。使用两种白内障分级系统在裂隙灯下对560名受试者的双眼晶状体进行分级。牛津临床白内障分类和分级系统(OCCCGS)采用标准图表和孟塞尔色样对皮质性、后囊下和核性白内障进行分级。晶状体混浊分类系统III(LOCS III)使用晶状体的摄影透明片作为标准。在这两种系统中,均给出一个十进制评分。我们还使用OCCCGS对LOCS III标准图像进行分级。计算了两种分级系统的观察者间差异。针对每种类型的晶状体混浊绘制了线性校准线。
核性白内障和后囊下白内障的LOCS III与OCCCGS之间的关系是线性的。对于皮质性白内障,一旦将LOCS III评分平方,其关系就是线性的。使用OCCCGS由人眼对LOCS III图像进行排序时,图像之间的间隔是线性的。两种系统的观察者间差异良好。
线性校准线可用于在两种系统之间进行转换,有助于比较研究或进行荟萃分析。这些结果表明,使用不同临床分级方案的白内障研究数据可以进行比较。