Shen D, Wang Y
Department of Nuclear Medicine, Space Central Hospital, No. 15 Yu Quan Lu, Beijing, People's Republic of China.
Mil Med. 1998 Feb;163(2):120-1.
This study examined the effect of high-altitude exposure on the plasma levels of certain peptides in the regulation of heart and blood vessels. The plasma levels of dynorphin A, neurotensin, and somatostatin were measured in 30 pilots before and after exposure to hypoxia in an altitude chamber. The results showed that plasma concentrations of the three peptides were increased significantly after exposure to hypoxia. In the test group, 18 pilots lived on a plateau (1,725 m above sea level); the other 12 pilots lived on a plain (208 m above sea level). When exposed to hypoxia, the three peptides increased significantly in the plateau group, but in the plain group, neurotensin and dynorphin A increased but somatostatin had no significant change. These results indicate that these peptides might participate in the regulation of cardiovascular activities under hypoxia.
本研究检测了高原暴露对某些肽类血浆水平在心脏和血管调节中的影响。在海拔舱内对30名飞行员进行低氧暴露前后，测定了强啡肽A、神经降压素和生长抑素的血浆水平。结果显示，低氧暴露后这三种肽的血浆浓度显著升高。试验组中，18名飞行员生活在高原（海拔1725米）；另外12名飞行员生活在平原（海拔208米）。低氧暴露时，高原组这三种肽显著升高，但平原组中，神经降压素和强啡肽A升高，而生长抑素无显著变化。这些结果表明，这些肽可能参与低氧状态下心血管活动的调节。
