De los Santos A R, Martí M I, Espinosa D, Di Girolamo G, Vinacur J C, Casadei A
School of Medicine, Department of Medicine, Universidad de Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1998;48(1):52-8.
This study was conducted to compare the analgesic action of Lysine Clonixinate (LC) vs Paracetamol/Codeine association (PC) in the treatment of postepisiotomy pain in primiparae women: 131 primiparous patients with moderate-to-severe postepisiotomy pain were enrolled in a double blind dummy design study and randomly allocated to either treatment with fixed doses of LC 125 mg or Paracetamol 500 mg+Codeine 30 mg 6 qh during 24 hours. Intensity of spontaneous pain and pain on walking was assessed according to a visual analog scale (VAS) and patient's assessment before receiving treatment and after 1, 2, 6 and 24 hours. Intensity of spontaneous pain was reduced in 24 hours from 4.28 +/- 2.11 to 1.73 +/- 1.46 (P < 0.0001) in the LC group and from 4.78 +/- 2.08 to 1.90 +/- 1.72 in the PC-treated group (p < 0.0001); with no significant differences between treatments. 54% of the patients treated with LC and 55% of those receiving PC showed onset of analgesic action 30 minutes following dose administration. Patient's final global assessment revealed that 95% of LC-treated patients and 96% of the PC group showed total or partial pain relief during the first treatment day. No sleep disturbances were seen during the night in 75% of patients. Only one patient receiving LC showed nausea not requiring treatment discontinuation. It is concluded that both treatments are equally effective to relieve moderate-to-severe postepisiotomy pain.
本研究旨在比较氯尼辛赖氨酸（LC）与对乙酰氨基酚/可待因组合（PC）在初产妇会阴切开术后疼痛治疗中的镇痛作用：131例中度至重度会阴切开术后疼痛的初产妇患者参加了一项双盲虚拟设计研究，并被随机分配接受固定剂量的LC 125mg治疗，或在24小时内每6小时接受对乙酰氨基酚500mg + 可待因30mg治疗。根据视觉模拟量表（VAS）以及患者在接受治疗前、治疗后1、2、6和24小时的评估，对自发痛和行走时的疼痛强度进行评估。LC组自发痛强度在24小时内从4.28±2.11降至1.73±1.46（P < 0.0001），PC治疗组从4.78±2.08降至1.90±1.72（p < 0.0001）；治疗之间无显著差异。接受LC治疗的患者中有54%和接受PC治疗的患者中有55%在给药后30分钟显示出镇痛作用开始。患者的最终总体评估显示，95%接受LC治疗的患者和96%的PC组患者在第一个治疗日期间显示出完全或部分疼痛缓解。75%的患者夜间未出现睡眠障碍。仅1例接受LC治疗的患者出现恶心，无需停药。结论是两种治疗在缓解中度至重度会阴切开术后疼痛方面同样有效。
