Rastogi S C, Johansen J D, Frosch P, Menné T, Bruze M, Lepoittevin J P, Dreier B, Andersen K E, White I R
Department of Environmental Chemistry, National Environmental Research Institute, Roskilde, Denmark.
Contact Dermatitis. 1998 Jan;38(1):29-35. doi: 10.1111/j.1600-0536.1998.tb05633.x.
Deodorants are one of the most frequently used types of cosmetics and side-effects from them are common. Recent studies relate perfume allergy to this type of product. 73 deodorants were analyzed by gas chromatography--mass spectrometry for the determination of the contents of 7 wellknown fragrance allergens from the fragrance mix and 14 other commonly used fragrance materials. The deodorants were purchased at retail outlets in 5 European countries. It was found that in general, fragrance mix ingredients were more frequently present in vapo- and aerosol sprays than in roll-on products. The levels of the fragrance mix substances ranged from 0.0001-0.2355%. The products investigated contained cinnamic aldehyde and isoeugenol less frequently (17% and 29% respectively), and eugenol and geraniol most frequently (57% and 76% respectively). The 14 other fragrance materials were found in 40-97% of the deodorants, with hedione and benzyl acetate the most frequently found substances. The concentration of these 14 substances ranged from 0.0001-2.7%. It is concluded that the levels of cinnamic aldehyde and isoeugenol found in the deodorants could prove to be relevant for elicitation of contact dermatitis. No conclusions could be drawn about the other fragrance mix constituents, as threshold levels in sensitized individuals have not been investigated. Furthermore, all of the fragrance materials investigated were frequently found in deodorants and, apart from the fragrance mix ingredients, the extent of problems with sensitization to these fragrance materials is largely unknown.
除臭剂是最常用的化妆品类型之一，其副作用很常见。最近的研究将香水过敏与这类产品联系起来。通过气相色谱 - 质谱法对73种除臭剂进行分析，以测定香精混合物中7种知名香料过敏原和其他14种常用香料成分的含量。这些除臭剂是在5个欧洲国家的零售商店购买的。结果发现，一般来说，香精混合物成分在喷雾和气雾剂产品中比在走珠式产品中更常见。香精混合物物质的含量范围为0.0001 - 0.2355%。所调查的产品中肉桂醛和异丁香酚的含量较少（分别为17%和29%），而丁香酚和香叶醇的含量最常见（分别为57%和76%）。在40 - 97%的除臭剂中发现了其他14种香料成分，其中铃兰醛和乙酸苄酯是最常见的物质。这14种物质的浓度范围为0.0001 - 2.7%。得出的结论是，除臭剂中发现的肉桂醛和异丁香酚含量可能与引发接触性皮炎有关。对于其他香精混合物成分无法得出结论，因为尚未研究致敏个体的阈值水平。此外，所有研究的香料成分在除臭剂中都很常见，除了香精混合物成分外，对这些香料成分致敏问题的程度在很大程度上尚不清楚。
