Laskawi R, Drobik C, Schönebeck C
Department of Otolaryngology-Head and Neck Surgery, University of Göttingen, Germany.
Laryngoscope. 1998 Mar;108(3):381-4. doi: 10.1097/00005537-199803000-00013.
Several therapeutic approaches exist to treat gustatory sweating (Frey's syndrome) following parotidectomy. Because of the lack of effective treatment, a new therapeutic modality using botulinum toxin injections was presented previously by our group. The duration of the demonstrated positive effect was essentially unknown so far. Based on our experiences using this technique since December 1993, the purpose of this clinical investigation was to make an up-to-date report and demonstrate the duration of effect of BOTOX injections in patients with severe gustatory sweating. Nineteen patients with severe gustatory sweating have been treated with BOTOX by intracutaneous injections into the affected skin areas. The maximal follow-up time was 33 months. The results were obtained by interviews and controls using Minor's starch iodine test. In all treated cases (n = 19 patients, 22 treated sides) gustatory sweating ceased completely within 2 days. Side effects were absent. In 12 patients gustatory sweating reappeared. The mean duration of effect was 17.3 months (subjective personal communication of 18 patients). Findings show that intracutaneous injection of BOTOX is a highly effective, safe, and minimally invasive treatment of Frey's syndrome with long-lasting therapeutic effect.
腮腺切除术后治疗味觉性出汗（弗雷综合征）有几种治疗方法。由于缺乏有效的治疗方法，我们团队之前提出了一种使用肉毒杆菌毒素注射的新治疗方式。到目前为止，所证明的积极效果的持续时间基本上还不清楚。基于我们自1993年12月以来使用该技术的经验，这项临床研究的目的是提供一份最新报告，并证明肉毒杆菌毒素注射对严重味觉性出汗患者的疗效持续时间。19例严重味觉性出汗患者通过皮内注射肉毒杆菌毒素对受影响的皮肤区域进行治疗。最长随访时间为33个月。结果通过访谈和使用米诺氏淀粉碘试验进行对照获得。在所有治疗病例（n = 19例患者，22个治疗侧）中，味觉性出汗在2天内完全停止。无副作用。12例患者味觉性出汗复发。平均疗效持续时间为17.3个月（18例患者的主观个人交流）。研究结果表明，皮内注射肉毒杆菌毒素是治疗弗雷综合征的一种高效、安全且微创的方法，具有持久的治疗效果。
