Butcher G W, King G, Dyke K G
J Gen Microbiol. 1976 Jun;94(2):290-6. doi: 10.1099/00221287-94-2-290.
Some unsaturated fatty acids were found to inhibit the growth of Staphylococcus aureus. Their effectiveness was related both to the degree of unsaturation and to the configuration of the molecule about the double bonds. Both linoleic acid and linolenic acid increased the proportion of plasmid-negative bacteria in a growing culture of bacteria containing a penicillinase plasmid. This was not due to a 'curing' effect of the fatty acids but was the result of greater sensitivity of the growth of bacteria containing penicillinase plasmid to inhibition by the unsaturated fatty acids. The presence of a plasmid conferring resistance to tetracycline, however, did not make the bacterium more sensitive to inhibition by linoleic or linolenic acids.
一些不饱和脂肪酸被发现可抑制金黄色葡萄球菌的生长。它们的有效性既与不饱和度有关，也与分子中双键周围的构型有关。亚油酸和亚麻酸均可增加含有青霉素酶质粒的细菌生长培养物中质粒阴性细菌的比例。这并非是由于脂肪酸的“消除”作用，而是含有青霉素酶质粒的细菌生长对不饱和脂肪酸抑制作用更敏感的结果。然而，携带四环素抗性的质粒的存在并没有使细菌对亚油酸或亚麻酸的抑制作用更敏感。
