Lacey R W, Lord V L
J Med Microbiol. 1981 Feb;14(1):41-9. doi: 10.1099/00222615-14-1-41.
The inhibition of coagulase-negative staphylococci and Staphylococcus aureus of human or animal origin by most free fatty acids was similar, but coagulase-positive staphylococci were sensitive and coagulase-negative cultures were resistant to linolenic acid. Animal strains of S. aureus were more sensitive to linolenic acid than were human strains. These differences were reflected in the relative abilities of the three categories of strains to survive on human skin. The antibacterial effects of 20 mg of linolenic acid were inactivated by 1 ml of serum in vitro. A test organism seeded on to skin also survived better if first suspended in serum. The mechanism of the interaction between serum and linolenic acid may be due to a detergent effect of the serum and could account for colonisation of diseased skin with S. aureus. Cultures of S. aureus seeded on to human skin were rapidly killed after the skin has been covered with linolenic acid. The possibility of therapeutic use of linolenic acid as an antibacterial agent should be explored.
大多数游离脂肪酸对人源或动物源凝固酶阴性葡萄球菌和金黄色葡萄球菌的抑制作用相似，但凝固酶阳性葡萄球菌对亚麻酸敏感，而凝固酶阴性培养物对亚麻酸耐药。金黄色葡萄球菌的动物菌株比人类菌株对亚麻酸更敏感。这些差异反映在这三类菌株在人皮肤上存活的相对能力上。在体外，20毫克亚麻酸的抗菌作用会被1毫升血清灭活。接种到皮肤上的试验微生物如果先悬浮在血清中，也能更好地存活。血清与亚麻酸之间相互作用的机制可能是由于血清的去污剂作用，这可以解释金黄色葡萄球菌在患病皮肤上的定植。在皮肤上覆盖亚麻酸后，接种到人体皮肤上的金黄色葡萄球菌培养物会迅速被杀死。应该探索将亚麻酸用作抗菌剂进行治疗的可能性。
