Diamond F B, Shulman D I, Lacson A, Casadonte J, Favara B
Department of Pediatrics, University of South Florida College of Medicine, Tampa, USA.
J Pediatr. 1998 Feb;132(2):357-60. doi: 10.1016/s0022-3476(98)70462-7.
Langerhans cell histiocytosis may be seen with goiter and histiocytic infiltration of the thyroid. We report a 2 1/2-year-old boy who had goiter and primary hypothyroidism develop, later had pulmonary disease, and died of neurologic involvement. Autopsy lesions suggested a transitional dendritic cell precursor of the epidermal Langerhans cell. Of the reported cases of Langerhans cell histiocytosis with goiter in children and adolescents, 82% were male when the relative incidence of Langerhans cell histiocytosis is two males to one female.
朗格汉斯细胞组织细胞增多症可能伴有甲状腺肿和甲状腺组织细胞浸润。我们报告了一名2岁半的男孩，他患有甲状腺肿并发展为原发性甲状腺功能减退，随后出现肺部疾病，最终死于神经系统受累。尸检病变提示为表皮朗格汉斯细胞的过渡性树突状细胞前体。在已报道的儿童和青少年朗格汉斯细胞组织细胞增多症合并甲状腺肿的病例中，82%为男性，而朗格汉斯细胞组织细胞增多症的相对发病率为男性与女性之比为2:1。
