Bairati I, Meyer F, Fradet Y, Moore L
Département de Médecine Sociale et Préventive, Centre de Recherche en Cancérologie de l'Université Laval, Quebec City, Quebec, Canada.
J Urol. 1998 Apr;159(4):1271-5.
We identify the dietary factors, particularly fat intake, associated with advanced prostate cancer.
We performed a case series analysis restricted to prostate cancer cases recruited in a hospital based, case control study evaluating the influence of diet on the development of prostate cancer. Patients eligible for study inclusion were 45 years old or older with prostate cancer who had been hospitalized for initial surgical treatment or radiotherapy between October 1990 and December 1992 at 1 of 8 hospitals in the Quebec City area. A diet history questionnaire was administered to 427 patients with prostate cancer of whom 384 (90%) had completed a reliable questionnaire, including 142 with advanced and 242 with local stages I and II disease. Logistic regression analysis was used to evaluate the associations between dietary intake and advanced prostate cancer. Odds ratios and trend odds ratios were adjusted for patient age, energy intake, method of cancer detection and cancer treatment.
There was a moderate, not statistically significant relation to total fat (trend odds ratio 1.15, confidence interval [CI] 0.95 to 1.39). Cases in the highest quartile of saturated fat consumption had a statistically significant odds ratio of 2.15 (CI 1.14 to 4.04). In addition, the relation increased proportionally and significantly with saturated fat intake (trend odds ratio 1.24, CI 1.02 to 1.51). Inverse associations of borderline significance were observed between advanced cancer, and polyunsaturated fat (trend odds ratio 0.88, CI 0.73 to 1.07) and linoleic acid intake (trend odds ratio 0.86, CI 0.71 to 1.04). A positive trend was observed for total animal fat intake (trend odds ratio 1.20, CI 0.99 to 1.46), while a negative trend was noted for total vegetable fat intake (trend odds ratio 0.84, CI 0.70 to 1.01).
This study suggests an association between saturated fat consumption and prostate cancer progression. If cohort studies performed on patients with local prostate cancer confirm these results, dietary fat intake modification may be a promising intervention to prevent prostate cancer progression.
我们确定与晚期前列腺癌相关的饮食因素，尤其是脂肪摄入量。
我们进行了一项病例系列分析，该分析仅限于在一项基于医院的病例对照研究中招募的前列腺癌病例，该研究评估饮食对前列腺癌发生发展的影响。符合研究纳入标准的患者为45岁及以上的前列腺癌患者，他们于1990年10月至1992年12月期间在魁北克市地区的8家医院中的1家因初次手术治疗或放疗而住院。对427例前列腺癌患者进行了饮食史问卷调查，其中384例（90%）完成了一份可靠的问卷，包括142例晚期患者和242例I期和II期局部疾病患者。采用逻辑回归分析来评估饮食摄入量与晚期前列腺癌之间的关联。对患者年龄、能量摄入量、癌症检测方法和癌症治疗方法进行了优势比和趋势优势比的调整。
总脂肪摄入量与之存在中度关联，但无统计学意义（趋势优势比1.15，置信区间[CI]为0.95至1.39）。饱和脂肪消耗量处于最高四分位数的病例，其优势比具有统计学意义，为2.15（CI为1.14至4.04）。此外，这种关联随着饱和脂肪摄入量的增加而成比例且显著增加（趋势优势比1.24，CI为1.02至1.51）。在晚期癌症与多不饱和脂肪（趋势优势比0.88，CI为0.73至1.07）和亚油酸摄入量（趋势优势比0.86，CI为0.71至1.04）之间观察到临界显著的负相关。总动物脂肪摄入量呈正趋势（趋势优势比1.20，CI为0.99至1.46），而总植物脂肪摄入量呈负趋势（趋势优势比0.84，CI为0.70至1.01）。
本研究表明饱和脂肪消耗与前列腺癌进展之间存在关联。如果对局部前列腺癌患者进行的队列研究证实这些结果，那么改变饮食脂肪摄入量可能是预防前列腺癌进展的一种有前景的干预措施。
