细菌性脑膜炎患者脑脊液中的β-微球蛋白浓度降低。

Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis.

作者信息

Tumani H, Reiber H, Nau R, Prange H W, Kauffmann K, Mäder M, Felgenhauer K

机构信息

Department of Neurology, University of Göttingen, Germany.

出版信息

Neurosci Lett. 1998 Feb 6;242(1):5-8. doi: 10.1016/s0304-3940(98)00021-4.

DOI:10.1016/s0304-3940(98)00021-4

PMID:9509992

Abstract

Although meninges represent a major site of biosynthesis, beta-trace protein (beta-trace) has not been studied in the cerebrospinal fluid (CSF) of meningitis patients. We measured beta-trace in lumbar CSF of normal controls (n = 27) and in patients with various neurological diseases (n = 92) by an immunonephelometric assay. The mean concentration of beta-trace in CSF of control patients was 16.6+/-3.6 mg/l. In bacterial meningitis (n = 41), CSF beta-trace was significantly decreased (8.7+/-3.9 mg/l; P< 0.001), whereas in spinal canal stenosis it was elevated (29.2+/-10.3 mg/l; P= 0.002). In viral meningoencephalitis (n = 12), beta-trace CSF concentrations were normal. Beta-trace concentrations remained below the normal range even after curing of bacterial meningitis, and normalisation of CSF leucocytes and blood-CSF barrier function. Beta-trace may be a useful tool for studying the pathophysiology of bacterial meningitis.

摘要

尽管脑膜是生物合成的主要部位，但尚未对脑膜炎患者脑脊液（CSF）中的β-微量蛋白（β-微量）进行研究。我们采用免疫比浊法检测了正常对照者（n = 27）和各种神经系统疾病患者（n = 92）腰椎脑脊液中的β-微量。对照患者脑脊液中β-微量的平均浓度为16.6±3.6 mg/l。在细菌性脑膜炎患者（n = 41）中，脑脊液β-微量显著降低（8.7±3.9 mg/l；P<0.001），而在椎管狭窄患者中则升高（29.2±10.3 mg/l；P = 0.002）。在病毒性脑膜脑炎患者（n = 12）中，脑脊液β-微量浓度正常。即使细菌性脑膜炎治愈后，脑脊液白细胞和血脑屏障功能恢复正常，β-微量浓度仍低于正常范围。β-微量可能是研究细菌性脑膜炎病理生理学的有用工具。