Immunologically active zones in bovine growth hormone.

Antigenic determinant areas were detected in bovine growth hormone fragments 6--124 and 125--149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53--164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity found in fragment 6--124 seems to be concentrated in the sequence 87--124.