Leon D A
Department of Epidemiology and Population Sciences, London School of Hygiene & Tropical Medicine, UK.
Eur J Clin Nutr. 1998 Jan;52 Suppl 1:S72-8; discussion S78-82.
Current knowledge on associations between variations in fetal growth on the one hand and blood pressure, noninsulin dependent diabetes, coronary heart disease and cancer in adulthood on the other is reviewed and related to more conventional preoccupations of perinatal epidemiology. Commonly used definitions and indicators of impaired fetal growth, possible explanations and mechanisms of the association between fetal growth impairment and later disease, and the concept and operational definitions of programming are discussed. Implications and research priorities that can be derived from this information are presented.
本文综述了目前关于胎儿生长变化与成人血压、非胰岛素依赖型糖尿病、冠心病和癌症之间关联的知识，并将其与围产期流行病学中更传统的关注点联系起来。讨论了胎儿生长受限常用的定义和指标、胎儿生长受限与后期疾病之间关联的可能解释和机制，以及程序化的概念和操作定义。还介绍了从这些信息中可以得出的意义和研究重点。
