Schimming R, Hlawitschka M, Haroske G, Eckelt U
Department of Maxillo-Facial Surgery, Dresden University of Technology, Germany.
Anal Quant Cytol Histol. 1998 Feb;20(1):43-51.
To evaluate the relation of DNA content of squamous cell carcinomas of the oral cavity to clinicopathologic features by image cytometry.
A series of 52 patients with operable oral cavity carcinomas at stage T1-4 and NO-3 were studied. The tumors were classified according to the TNM classification and graded histopathologically.
A positive correlation between tumor size and ploidy status was observed. There was a significant correlation between ploidy status and histologically proven existence of cervical lymph node metastases (61% nondiploid versus 29% diploid, P < .03). A relationship between histopathologic grade and ploidy status could not be proven. The cumulative five-year survival rate among patients with diploid DNA findings as opposed to those with nondiploid findings was significantly increased (P < .03).
When assessing the prognosis of squamous cell carcinomas, DNA cytometry analysis can be used as an additional method. The significantly higher N stage, a higher frequency of metastases and a significantly lower survival rate with nondiploid tumors underline the importance of this examination method.
通过图像细胞术评估口腔鳞状细胞癌的DNA含量与临床病理特征之间的关系。
对52例T1 - 4期、NO - 3期可手术切除的口腔癌患者进行了研究。肿瘤根据TNM分类进行分类，并进行组织病理学分级。
观察到肿瘤大小与倍体状态之间存在正相关。倍体状态与经组织学证实的颈部淋巴结转移存在显著相关性（非二倍体为61%，二倍体为29%，P <.03）。组织病理学分级与倍体状态之间的关系未得到证实。与非二倍体结果的患者相比，二倍体DNA结果的患者累积五年生存率显著提高（P <.03）。
在评估鳞状细胞癌的预后时，DNA细胞术分析可作为一种辅助方法。非二倍体肿瘤的N分期显著更高、转移频率更高且生存率显著更低，这突出了这种检查方法的重要性。
