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Effect of pentoxifylline on immotile testicular spermatozoa.己酮可可碱对不动的睾丸精子的作用。
J Assist Reprod Genet. 1998 Feb;15(2):90-2. doi: 10.1007/BF02766832.
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In-vitro fertilization treatment for severe male factor: the fertilization potential of immotile spermatozoa obtained by testicular extraction.重度男性因素的体外受精治疗：经睾丸提取获得的无活动力精子的受精潜力。
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本文引用的文献

1
The use of testicular sperm for intracytoplasmic sperm injection in patients with necrozoospermia.
Fertil Steril. 1996 Aug;66(2):331-4. doi: 10.1016/s0015-0282(16)58462-3.
2
Correlation between testicular histology and outcome after intracytoplasmic sperm injection using testicular spermatozoa.使用睾丸精子进行卵胞浆内单精子注射后睾丸组织学与结局的相关性。
Hum Reprod. 1996 Jan;11(1):127-32. doi: 10.1093/oxfordjournals.humrep.a019004.
3
Pentoxifylline-enhanced acrosome reaction correlates with fertilization in vitro.己酮可可碱增强的顶体反应与体外受精相关。
Hum Reprod. 1993 Dec;8(12):2102-7. doi: 10.1093/oxfordjournals.humrep.a137990.
4
Fertility in men with primary ciliary dyskinesia presenting with respiratory infection.原发性纤毛运动障碍伴呼吸道感染男性的生育能力
Thorax. 1994 Jul;49(7):684-7. doi: 10.1136/thx.49.7.684.
5
Pregnancy after fertilisation with human testicular spermatozoa.
Lancet. 1993 Nov 13;342(8881):1237. doi: 10.1016/0140-6736(93)92217-h.
6
Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia.
Hum Reprod. 1995 Jun;10(6):1457-60. doi: 10.1093/humrep/10.6.1457.

己酮可可碱对不动的睾丸精子的作用。

Effect of pentoxifylline on immotile testicular spermatozoa.

作者信息

Taşdemir I, Taşdemir M, Tavukçuoğlu S

机构信息

FERTILITE Reproductive Science Center, Istanbul, Turkey.

出版信息

J Assist Reprod Genet. 1998 Feb;15(2):90-2. doi: 10.1007/BF02766832.

DOI:10.1007/BF02766832
PMID:9513848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455426/
Abstract

PURPOSE

A model for differentiating live and dead sperm cells during intracytoplasmic sperm injection (ICSI) is proposed.

METHODS

We used pentoxifylline, a phosphodiesterase inhibitor known to enhance sperm motility, to initiate motility in testicular spermatozoa. Ten immotile testicular sperm samples were divided into two parts for examination of sperm motility with and without pentoxifylline treatment at 30, 60, and 90 min.

RESULTS

The samples without pentoxifylline remained immotile even after 90 min of incubation: the addition of pentoxifylline initiated sperm motility in all samples: 51.8 +/- 10.2, 64.4 +/- 9.4, and 70.8 +/- 8.9% (mean +/- SD) at 30, 60, and 90 min, respectively.

CONCLUSIONS

That pentoxifylline may be used to differentiate live testicular spermatozoa during ICSI, which may improve fertilization and pregnancy rates, is suggested.

摘要

目的

提出一种在卵胞浆内单精子注射（ICSI）过程中区分活精子细胞和死精子细胞的模型。

方法

我们使用己酮可可碱，一种已知可增强精子活力的磷酸二酯酶抑制剂，来启动睾丸精子的活力。将10个无活力的睾丸精子样本分成两部分，分别在30、60和90分钟时检测有无己酮可可碱处理情况下的精子活力。

结果

未用己酮可可碱处理的样本即使孵育90分钟后仍无活力；添加己酮可可碱后所有样本均出现精子活力：在30、60和90分钟时分别为51.8±10.2%、64.4±9.4%和70.8±8.9%（平均值±标准差）。

结论

提示己酮可可碱可用于在ICSI过程中区分活的睾丸精子，这可能提高受精率和妊娠率。