Biederman J, Faraone S V, Taylor A, Sienna M, Williamson S, Fine C
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA.
J Am Acad Child Adolesc Psychiatry. 1998 Mar;37(3):305-13. doi: 10.1097/00004583-199803000-00016.
To determine whether there are differences in the clinical expression and correlates of attention-deficit hyperactivity disorder (ADHD) between children and adolescents.
Subjects were 6- to 17-year old Caucasian, non-Hispanic boys with and without ADHD. DSM-III-R structured diagnostic interviews, psychometric measures, and blind raters assessed psychiatric diagnoses, intellectual performance, social disability, school failure, and family functioning.
Children and adolescents with ADHD had an almost identical pattern of correlates in multiple domains of assessment including psychosocial adversity and comorbidity with conduct, mood, and anxiety disorders. Although the rate of substance abuse differed in comparison between child and adolescent subjects, this was independent of ADHD status.
These findings document the diagnostic continuity of ADHD between childhood and adolescence and support the inclusion of adolescent samples in ADHD research protocols.
确定儿童和青少年注意力缺陷多动障碍（ADHD）的临床表型及相关因素是否存在差异。
研究对象为6至17岁的白种非西班牙裔男孩，分为患ADHD组和未患ADHD组。采用DSM-III-R结构化诊断访谈、心理测量方法，由盲法评估者对精神疾病诊断、智力表现、社会功能缺陷、学业失败及家庭功能进行评估。
患ADHD的儿童和青少年在多个评估领域，包括心理社会逆境以及与品行、情绪和焦虑障碍的共病情况，具有几乎相同的相关模式。尽管儿童和青少年样本中药物滥用率的比较存在差异，但这与ADHD状态无关。
这些研究结果证明了ADHD在儿童期和青少年期的诊断连续性，并支持将青少年样本纳入ADHD研究方案。
