Huang C C, Chu N S, Lu C S, Chen R S, Calne D B
Department of Neurology, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan.
Neurology. 1998 Mar;50(3):698-700. doi: 10.1212/wnl.50.3.698.
We studied the long-term clinical course of five patients with chronic manganese intoxication. The mean scores of the King's College Hospital Rating Scale for Parkinson's disease increased from 15.0 +/- 4.2 in 1987 to 28.3 +/- 6.70 in 1991 and then to 38.1 +/- 12.9 in 1995. The deterioration was most prominent in gait, rigidity, speed of foot tapping, and writing. Tissue concentrations of manganese in blood, urine, scalp hair, and pubic hair returned to normal. Follow-up MRIs did not show paramagnetic high-signal intensity on T1-weighted images. The data indicate that clinical progression in patients with manganese parkinsonism continues even 10 years after cessation of exposure.
我们研究了5例慢性锰中毒患者的长期临床病程。帕金森病国王学院医院评定量表的平均得分从1987年的15.0±4.2增加到1991年的28.3±6.70，然后在1995年增至38.1±12.9。步态、僵硬、足部轻敲速度和书写方面的恶化最为明显。血液、尿液、头皮毛发和阴毛中的锰组织浓度恢复正常。随访的磁共振成像在T1加权图像上未显示顺磁性高信号强度。数据表明，锰中毒帕金森综合征患者即使在接触停止10年后临床仍在进展。
