Aldoori W H, Giovannucci E L, Rockett H R, Sampson L, Rimm E B, Willett W C
Department of Nutrition, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
J Nutr. 1998 Apr;128(4):714-9. doi: 10.1093/jn/128.4.714.
To examine prospectively dietary fiber calculated from food composition values based on analytic techniques and specific dietary fiber types in relation to risk of diverticular disease, we analyzed data from a prospective cohort of 43,881 U.S. male health professionals 40-75 y of age at base line; subjects were free of diagnosed diverticular disease, colon or rectal polyps, ulcerative colitis and cancer. The insoluble component of fiber was inversely associated with risk of diverticular disease relative risk (RR) = 0. 63, 95% confidence interval (CI), 0.44-0.91, P for trend = 0.02, and this association was particularly strong for cellulose (RR = 0.52, 95% CI, 0.36-0.75, P for trend = 0.002). The association between diverticular disease and total dietary fiber intake calculated from the AOACstandards method was not appreciably different from results using the Southgate or Englyst method [for AOAC method, RR = 0.60, 95% CI, 0.41-0.87; for Southgate method, RR = 0.61, 95% CI, 0.42-0. 88; for Englyst method, RR = 0.60, 95% CI, 0.42-0.87, for the highest quintiles]. Our findings provide evidence for the hypothesis that a diet high in dietary fiber decreases the risk of diverticular disease, and this result was not sensitive to the use of different analytic techniques to define dietary fiber. Our findings suggest that the insoluble component of fiber was significantly associated with a decreased risk of diverticular disease, and this inverse association was particularly strong for cellulose.
为了前瞻性地研究基于分析技术从食物成分值计算得出的膳食纤维及特定膳食纤维类型与憩室病风险之间的关系，我们分析了来自一个前瞻性队列的数据，该队列由43881名40 - 75岁的美国男性健康专业人员组成，基线时他们均未被诊断患有憩室病、结肠或直肠息肉、溃疡性结肠炎和癌症。纤维的不溶性成分与憩室病风险呈负相关[相对风险（RR）= 0.63，95%置信区间（CI），0.44 - 0.91，趋势P值 = 0.02]，并且这种关联在纤维素方面尤为显著（RR = 0.52，95% CI，0.36 - 0.75，趋势P值 = 0.002）。根据美国分析化学家协会（AOAC）标准方法计算的总膳食纤维摄入量与憩室病之间的关联，与使用南门特（Southgate）或恩格利斯特（Englyst）方法的结果没有明显差异[对于AOAC方法，RR = 0.60，95% CI，0.41 - 0.87；对于南门特方法，RR = 0.61，95% CI，0.42 - 0.88；对于恩格利斯特方法，最高五分位数的RR = 0.60，95% CI，0.42 - 0.87]。我们的研究结果为膳食纤维含量高的饮食可降低憩室病风险这一假设提供了证据，并且这一结果对于使用不同分析技术来定义膳食纤维并不敏感。我们的研究结果表明，纤维的不溶性成分与憩室病风险降低显著相关，并且这种负相关在纤维素方面尤为强烈。
