Aldoori W H, Giovannucci E L, Rimm E B, Wing A L, Trichopoulos D V, Willett W C
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115.
Am J Clin Nutr. 1994 Nov;60(5):757-64. doi: 10.1093/ajcn/60.5.757.
To examine the association between dietary fiber, sources of fiber, other nutrients, and the diagnosis of symptomatic diverticular disease, we analyzed data from a prospective cohort of 47,888 US men. During 4 y of follow-up we documented 385 new cases of symptomatic diverticular disease. Total dietary fiber intake was inversely associated with the risk of diverticular disease after adjustment for age, energy-adjusted total fat intake, and physical activity [relative risk (RR) 0.58; 95% CI 0.41, 0.83; P for trend = 0.01 for men in the highest as compared with the lowest quintile of dietary fiber]. This inverse association was primarily due to fruit and vegetable fiber. For men on a high-total-fat, low-fiber diet, the RR was 2.35 (95% CI 1.38, 3.98) compared with those on a low-total-fat, high-fiber diet, and for men on a high-red-meat, low-fiber diet the RR was 3.32 (95% CI 1.46, 7.53) compared with those on a low-red-meat, high-fiber diet. These prospective data support the hypothesis that a diet low in total dietary fiber increases the incidence of symptomatic diverticular disease. They also provide evidence that the combination of high intake of total fat or red meat and a diet low in total dietary fiber particularly augments the risk.
为研究膳食纤维、纤维来源、其他营养素与症状性憩室病诊断之间的关联，我们分析了来自47888名美国男性前瞻性队列的数据。在4年的随访期间，我们记录了385例新的症状性憩室病病例。在对年龄、能量调整后的总脂肪摄入量和身体活动进行调整后，总膳食纤维摄入量与憩室病风险呈负相关[相对风险（RR）为0.58；95%置信区间为0.41，0.83；膳食纤维摄入量最高五分位数与最低五分位数的男性相比，趋势P值=0.01]。这种负相关主要归因于水果和蔬菜纤维。与低脂高纤维饮食的男性相比，高脂低纤维饮食的男性RR为2.35（95%置信区间为1.38，3.98）；与低红肉高纤维饮食的男性相比，高红肉低纤维饮食的男性RR为3.32（95%置信区间为1.46，7.53）。这些前瞻性数据支持了总膳食纤维含量低的饮食会增加症状性憩室病发病率这一假设。它们还提供了证据表明，总脂肪或红肉的高摄入量与总膳食纤维含量低的饮食相结合尤其会增加风险。
