Aldoori W H, Giovannucci E L, Rimm E B, Wing A L, Trichopoulos D V, Willett W C
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Ann Epidemiol. 1995 May;5(3):221-8. doi: 10.1016/1047-2797(94)00109-7.
The relationship between smoking, caffeine, and alcohol intake and the risk of symptomatic diverticular disease has not been investigated directly. We examined these associations in a prospective cohort of 47,678 US men, 40 to 75 years old. During 4 years of follow-up (1988 to 1992), we documented 382 newly diagnosed cases of symptomatic diverticular disease. After adjustments for age, physical activity, and energy-adjusted intake of dietary fiber and total fat, alcohol intake (comparing those who drink > 30 g of alcohol/d to nondrinkers) was only weakly and nonsignificantly associated with risk of symptomatic diverticular disease (relative risk (RR) = 1.36; 95 percent confidence interval (CI), 0.94 to 1.97; P for trend = 0.37). We observed no association between caffeine, specific caffeinated beverages, and decaffeinated coffee and the risk of symptomatic diverticular disease. Current smoking was not appreciably associated with risk of symptomatic diverticular disease compared to nonsmokers (RR = 1.25; 95 percent CI, 0.75 to 2.09) after adjustment for age, physical activity, and energy-adjusted intake of dietary fiber and total fat. In a subset analysis restricted to men who had undergone sigmoidoscopy or colonoscopy, a modest positive association was seen between smoking and risk of symptomatic diverticular disease. These results suggest that smoking, caffeine, and alcohol intake are not associated with any substantially increased risk of symptomatic diverticular disease.
吸烟、咖啡因和酒精摄入量与有症状憩室病风险之间的关系尚未得到直接研究。我们在一个由47678名40至75岁美国男性组成的前瞻性队列中研究了这些关联。在4年的随访期（1988年至1992年）内，我们记录了382例新诊断的有症状憩室病病例。在对年龄、身体活动以及膳食纤维和总脂肪的能量调整摄入量进行校正后，酒精摄入量（将每天饮酒量>30克者与不饮酒者相比）与有症状憩室病风险仅存在微弱且无统计学意义的关联（相对风险（RR）=1.36；95%置信区间（CI），0.94至1.97；趋势检验P值=0.37）。我们未观察到咖啡因、特定含咖啡因饮料和脱咖啡因咖啡与有症状憩室病风险之间存在关联。在校正年龄、身体活动以及膳食纤维和总脂肪的能量调整摄入量后，与不吸烟者相比，当前吸烟者与有症状憩室病风险并无明显关联（RR = 1.25；95%CI，0.75至2.09）。在一项仅限于接受过乙状结肠镜检查或结肠镜检查男性的亚组分析中，吸烟与有症状憩室病风险之间存在适度的正相关。这些结果表明，吸烟、咖啡因和酒精摄入量与有症状憩室病风险的任何实质性增加均无关联。
