Wenzel R P, Hunting K J, Osterman C A, Sande M A
Am J Epidemiol. 1976 Aug;104(2):170-80. doi: 10.1093/oxfordjournals.aje.a112287.
The emergence of Providencia stuartii as a hospital pathogen in a burn unit was demonstrated by routine infection surveillance. The organism was initially recognized in a burn wound and subsequently in urine or sputum. Compared to controls, those patients harboring P. stuartii were similar in age and percentage of body surface burned and were more likely to have been in one of the two burn unit rooms, (p less than 0.02). Infection with P. stuartii was independent of duration in the Intensive Care Unit or Burn Unit, and of number of visits to hydrotherapy or operating rooms (OR). Once patients were colonized with P. stuartii they had greater morbidity than non-colonized patients as evidenced by longer stays in the unit and increased visits to the OR for debridement. P. stuartii was isolated from air samples (5/14) more commonly than from the hands of personnel. In vitro tests suggested that extensive use of parenteral gentamicin and replacement of the antibacterial topical cream sulfamylon by silver sulfadiazine favored the emergence of P. stuartii over Pseudomonas aeruginosa as the predominant colonizing organism.
通过常规感染监测证实，斯氏普罗威登斯菌已成为烧伤病房的医院病原体。该菌最初在烧伤创面被发现，随后在尿液或痰液中被发现。与对照组相比，携带斯氏普罗威登斯菌的患者在年龄和烧伤体表面积百分比方面相似，且更有可能住在两个烧伤病房中的一个（p<0.02）。感染斯氏普罗威登斯菌与在重症监护病房或烧伤病房的住院时间以及水疗或手术室（OR）的就诊次数无关。一旦患者被斯氏普罗威登斯菌定植，他们的发病率就会高于未定植的患者，这表现为在病房停留时间更长以及因清创而增加了去手术室的次数。从空气样本（5/14）中分离出斯氏普罗威登斯菌比从工作人员手上分离出该菌更为常见。体外试验表明，肠胃外广泛使用庆大霉素以及用磺胺嘧啶银替代抗菌外用乳膏磺胺米隆，有利于斯氏普罗威登斯菌取代铜绿假单胞菌成为主要的定植菌。
