HLA - B27在慢性关节炎中的致病作用。
The pathogenetic role of HLA-B27 in chronic arthritis.
作者信息
López de Castro J A
机构信息
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Facultad de Ciencias, Spain.
出版信息
Curr Opin Immunol. 1998 Feb;10(1):59-66. doi: 10.1016/s0952-7915(98)80033-2.
PMID:9523113
Abstract
Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.
摘要
在转基因啮齿动物中进行的群体和肽特异性分析及研究支持HLA - B27作为脊柱关节病中抗原呈递分子的作用。HLA - B27与感染细胞上的致关节炎细菌之间的相互作用表明，HLA - B27也可能通过其他机制影响疾病。最近的遗传学进展有望鉴定出更多的易感基因。
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