磷脂酰肌醇-3,4,5-三磷酸（PtdIns-3,4,5-P3）/Tec激酶依赖性钙信号通路：SHIP介导的抑制性信号的靶点。
Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.
作者信息
Scharenberg A M, El-Hillal O, Fruman D A, Beitz L O, Li Z, Lin S, Gout I, Cantley L C, Rawlings D J, Kinet J P
机构信息
Laboratory of Allergy and Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
出版信息
EMBO J. 1998 Apr 1;17(7):1961-72. doi: 10.1093/emboj/17.7.1961.
Abstract
Tec family non-receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell types, including an essential role in B-cell development. A unique feature of several Tec members among known tyrosine kinases is the presence of an N-terminal pleckstrin homology (PH) domain. We directly demonstrate that phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3) interacting with the PH domain acts as an upstream activation signal for Tec kinases, resulting in Tec kinase-dependent phospholipase Cgamma (PLCgamma) tyrosine phosphorylation and inositol trisphosphate production. In addition, we show that this pathway is blocked when an SH2-containing inositol phosphatase (SHIP)-dependent inhibitory receptor is engaged. Together, our results suggest a general mechanism whereby PtdIns-3,4,5-P3 regulates receptor-dependent calcium signals through the function of Tec kinases.
摘要
Tec家族非受体酪氨酸激酶参与了由多种细胞类型的细胞表面受体引发的信号转导事件，包括在B细胞发育中起关键作用。已知酪氨酸激酶中几个Tec成员的一个独特特征是存在N端普列克底物蛋白同源（PH）结构域。我们直接证明，与PH结构域相互作用的磷脂酰肌醇-3,4,5-三磷酸（PtdIns-3,4,5-P3）作为Tec激酶的上游激活信号，导致Tec激酶依赖性磷脂酶Cγ（PLCγ）酪氨酸磷酸化和肌醇三磷酸生成。此外，我们表明，当含SH2结构域的肌醇磷酸酶（SHIP）依赖性抑制性受体被激活时，该途径被阻断。总之，我们的结果提示了一种普遍机制，即PtdIns-3,4,5-P3通过Tec激酶的功能调节受体依赖性钙信号。
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本文引用的文献
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Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.Btk/Tec激酶调节B细胞受体激活后细胞内钙离子（Ca2+）的持续增加。
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Negative signaling pathways of the killer cell inhibitory receptor and Fc gamma RIIb1 require distinct phosphatases.杀伤细胞抑制性受体和FcγRIIb1的负向信号通路需要不同的磷酸酶。
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