Lesprit P, Scieux C, Lemann M, Carbonelle E, Modaï J, Molina J M
Department of Infectious Diseases, Hôpital Saint-Louis, Paris, France.
Clin Infect Dis. 1998 Mar;26(3):646-50. doi: 10.1086/514572.
We assessed the value of the cytomegalovirus (CMV) antigenemia assay for diagnosing primary CMV infection in adults. The CMV antigenemia assay was performed for 40 patients admitted to our unit over a 2-year period with unexplained fever and suspected primary CMV infection. Nine of the 10 patients with primary CMV infection had positive CMV antigenemia assays, and the results were available within 5 hours. All 10 patients had a mononucleosis-like syndrome. All but one of the 30 other patients had negative CMV antigenemia assays. A false-positive result was obtained for a patient with systemic lupus erythematosus. Overall, the CMV antigenemia assay was 90% sensitive and 96% specific for the diagnosis of primary CMV infection. Therefore, the CMV antigenemia assay appears to be a simple, rapid, inexpensive test for the diagnosis of primary CMV infection in hospitalized adults.
我们评估了巨细胞病毒（CMV）抗原血症检测在诊断成人原发性CMV感染中的价值。在两年期间，对入住我们科室的40例原因不明发热且疑似原发性CMV感染的患者进行了CMV抗原血症检测。10例原发性CMV感染患者中有9例CMV抗原血症检测呈阳性，且结果在5小时内可得。所有10例患者均有单核细胞增多症样综合征。其他30例患者中除1例之外，CMV抗原血症检测均为阴性。1例系统性红斑狼疮患者出现假阳性结果。总体而言，CMV抗原血症检测诊断原发性CMV感染的敏感性为90%，特异性为96%。因此，CMV抗原血症检测似乎是一种用于诊断住院成人原发性CMV感染的简单、快速且廉价的检测方法。
