Condie R G
Br J Obstet Gynaecol. 1976 Aug;83(8):636-9. doi: 10.1111/j.1471-0528.1976.tb00902.x.
A serial study of coagulation factors XII, XI and X in plasma has been carried out on 60 primigravidae, prospectively comparing those who remained normal with those who developed pre-eclampsia. In the normal group of 48 patients, the levels of all factors rose as pregnancy advanced, a secondary increase in factors XI and X occurring in the puerperium. Cord levels of all three factors were depressed. In the pre-eclampsia group of 12 patients, factor XII was significantly higher than in the normal group throughout the study, while factors XI and X were slightly lower. Observed changes failed to support the idea of a strong primary role for the coagulation mechanism in the pathogenesis of pre-eclampsia.
对60例初产妇进行了血浆凝血因子Ⅻ、Ⅺ和Ⅹ的系列研究，前瞻性地比较了仍保持正常的产妇和发生先兆子痫的产妇。在48例正常组患者中，随着妊娠进展，所有因子水平均升高，产后因子Ⅺ和Ⅹ出现二次升高。所有这三种因子的脐血水平均降低。在12例先兆子痫组患者中，在整个研究过程中，因子Ⅻ显著高于正常组，而因子Ⅺ和Ⅹ略低。观察到的变化不支持凝血机制在先兆子痫发病机制中起主要作用的观点。
