由非O1和O139血清群霍乱弧菌引起的类似霍乱疾病的关联
Association of a disease approximating cholera caused by Vibrio cholerae of serogroups other than O1 and O139.
作者信息
Bhattacharya M K, Dutta D, Bhattacharya S K, Deb A, Mukhopadhyay A K, Nair G B, Shimada T, Takeda Y, Chowdhury A, Mahalanabis D
机构信息
National Institute of Cholera & Enteric Diseases, Beliaghata, Calcutta, India.
出版信息
Epidemiol Infect. 1998 Feb;120(1):1-5. doi: 10.1017/s0950268897008352.
One hundred and six patients suffering from severe dehydrating diarrhoea were studied of whom 36 patients were positive for Vibrio cholerae. Out of 36, 15 were positive for V. cholerae O1, 10 for V. cholerae O139 and 11 for V. cholerae non-O1 non-O139. O1 and O139 were positive for the 301-bp ctxA amplicon and 471-bp tcpA amplicon indicating that the strains possessed toxigenic capability whereas no non-O1 non-O139 strain possessed ctxA or tcpA genes. Post-admission severity of purging and amount of ORS required were less in the V. cholerae non-O1 non-O139 group (P < 0.05) compared to the V. cholerae O1 and O139 groups. It appears from this study that a cholera-like clinical condition can be caused in the absence of CT as exemplified by strains of non-O1 non-O139.
对106例患有严重脱水腹泻的患者进行了研究，其中36例霍乱弧菌检测呈阳性。在这36例中，15例霍乱弧菌O1阳性，10例霍乱弧菌O139阳性，11例霍乱弧菌非O1非O139阳性。O1和O139的301 bp ctxA扩增子和471 bp tcpA扩增子呈阳性，表明这些菌株具有产毒能力，而没有非O1非O139菌株拥有ctxA或tcpA基因。与霍乱弧菌O1和O139组相比，霍乱弧菌非O1非O139组入院后腹泻严重程度和所需口服补液盐量较少（P<0.05）。从这项研究看来，如非O1非O139菌株所示，在没有霍乱毒素的情况下也可引发类似霍乱的临床症状。
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