Rokach J, Khanapure S P, Hwang S W, Adiyaman M, Lawson J A, FitzGerald G A
Claude Pepper Institute, Florida Institute of Technology, Melbourne 32901-6975, USA.
Prostaglandins. 1997 Dec;54(6):823-51. doi: 10.1016/s0090-6980(97)00183-4.
The isoprostanes are a new class of natural products produced in vivo by a non-enzymatic free-radical-induced peroxidation of polyunsaturated fatty acid. In the case of arachidonic acid, for example, four classes of isoprostanes can be produced. Because of the specific structural features distinguishing them from other free-radical-generated products, e.g., HETEs, etc., the isoprostanes can provide an exclusive and selective index for the oxidant component of several inflammatory and degenerative diseases. The possible mechanisms of formation of the individual isoprostanes is discussed in detail. Class III products, such as 8-iso-PGF2 alpha and 8-iso-PGE2 have been shown to be vasoconstrictors and modulate platelet function. Several synthetic representatives from the four classes of arachidonic-acid-derived isoprostanes have already been prepared by total synthesis. These synthetic standards have been used for the identification and quantitation of these isoprostanes in biological fluids using gas chromatography/mass spectrometry methodology.
异前列腺素是一类新的天然产物，由体内多不饱和脂肪酸的非酶自由基诱导过氧化反应产生。例如，在花生四烯酸的情况下，可以产生四类异前列腺素。由于其特定的结构特征使其区别于其他自由基生成产物，如羟二十碳四烯酸（HETEs）等，异前列腺素可为多种炎症和退行性疾病的氧化成分提供独特且具选择性的指标。文中详细讨论了各类异前列腺素可能的形成机制。Ⅲ类产物，如8-异前列腺素F2α和8-异前列腺素E2已被证明是血管收缩剂，并可调节血小板功能。四类花生四烯酸衍生的异前列腺素中的几种合成代表物已通过全合成制备出来。这些合成标准品已用于采用气相色谱/质谱分析法对生物体液中的这些异前列腺素进行鉴定和定量。
