Racine-Poon A, Wakefield J
Pharma Division, Novartis, Basel, Switzerland.
Stat Methods Med Res. 1998 Mar;7(1):63-84. doi: 10.1177/096228029800700106.
A principal aim of population pharmacokinetic studies is to estimate the variance components associated with intra- and inter-individual variability in observed drug concentrations. The explanation of the inter-individual variability in terms of subject-specific covariates is also of great importance. Pharmacokinetic models are nonlinear in the parameters and estimation is not straightforward. Within this paper we review a number of estimation approaches which have been suggested for population pharmacokinetic analyses. We distinguish between Bayesian and non-Bayesian and fully-parametric, semi-parametric and nonparametric methods.
群体药代动力学研究的一个主要目标是估计与观察到的药物浓度的个体内和个体间变异性相关的方差分量。根据个体特异性协变量解释个体间变异性也非常重要。药代动力学模型在参数方面是非线性的，估计并不直接。在本文中，我们回顾了一些为群体药代动力学分析建议的估计方法。我们区分了贝叶斯和非贝叶斯方法以及完全参数化、半参数化和非参数化方法。
