Peat J K, Dickerson J, Li J
Department of Medicine, University of Sydney, NSW, Australia.
Allergy. 1998 Feb;53(2):120-8. doi: 10.1111/j.1398-9995.1998.tb03859.x.
This review examines whether there is a direct or indirect relation between damp or mould in the home and respiratory health. Home dampness is thought to have health consequences because it has the potential to increase the proliferation of house-dust mites and moulds, both of which are allergenic. The results from the many studies conducted to investigate whether damp and mould are associated with health outcomes are difficult to compare because the methods of measuring exposures and health outcomes have not been standardized. However, the studies that have been conducted in children are probably the most reliable because the confounding effects of active smoking or occupational exposures are absent, and because the presence of symptoms of cough and wheeze have been consistently investigated in many studies. The increased risk of children having these symptoms if the home has damp or mould is fairly small with an odds ratio that is generally in the range 1.5-3.5, these estimates being statistically significant when the sample size has been large enough. This range is consistent with the measured effects of other environmental exposures which are considered important to health, such as environmental tobacco smoke or outdoor air pollutants. The potential benefits of reducing mould in the home have not been investigated, and the few studies that have investigated health improvements as a result of increasing ventilation or reducing damp in order to reduce house-dust mite levels suggest that this intervention is expensive, requires a large commitment, and is unlikely to be successful in the long term. This implies that houses need to be specifically designed for primary prevention of respiratory problems associated with indoor allergen proliferation rather than using post hoc procedures to improve indoor climate and reduce allergen load as a secondary or tertiary preventive strategy.
本综述探讨家中潮湿或霉菌与呼吸健康之间是否存在直接或间接关系。家庭潮湿被认为会对健康产生影响,因为它有可能增加屋尘螨和霉菌的繁殖,而这两者都具有致敏性。为调查潮湿和霉菌是否与健康结果相关而开展的众多研究,其结果难以比较,因为测量暴露因素和健康结果的方法尚未标准化。然而,针对儿童开展的研究可能最为可靠,这是因为不存在主动吸烟或职业暴露的混杂效应,而且许多研究一直都在持续调查咳嗽和喘息症状的存在情况。如果家中潮湿或有霉菌,儿童出现这些症状的风险虽有增加,但相当小,优势比通常在1.5至3.5的范围内,当样本量足够大时,这些估计值具有统计学意义。这个范围与其他被认为对健康很重要的环境暴露的测量效应一致,比如环境烟草烟雾或室外空气污染物。减少家中霉菌的潜在益处尚未得到研究,少数为调查增加通风或减少潮湿以降低屋尘螨水平对健康改善情况的研究表明,这种干预成本高昂,需要大量投入,且从长远来看不太可能成功。这意味着房屋需要专门设计,以从源头上预防与室内过敏原增殖相关的呼吸问题,而不是采用事后措施来改善室内气候和减少过敏原负荷,将其作为二级或三级预防策略。