Strachan D P
Department of Community Medicine, University of Edinburgh.
BMJ. 1988 Nov 12;297(6658):1223-6. doi: 10.1136/bmj.297.6658.1223.
The relations among parental reports of respiratory symptoms, bronchospasm measured after exercise, and the presence of visible fungal mould in the home was assessed in a population sample of 7 year old children (n = 873). Wheeze in the past year was the symptom most closely associated with reported dampness and particularly with mould. The unadjusted odds ratio relating mould and wheeze was 3.70 (95% confidence interval 2.22 to 6.15), and after adjustment for housing tenure, number of people per room, number of smokers in the household, and gas cooking this remained highly significant (odds ratio 3.00 (1.72 to 5.25)). The reduction in forced expiratory volume in one second after six minutes of free running was used to validate reporting of wheeze. At all levels of measured bronchial lability wheeze was reported more commonly in the children from homes with mould. There was no significant difference in the degree of bronchospasm measured among children from homes with and without mould. Awareness of dampness or mould in the home may be a determinant of parental reporting of symptoms and may account for much of the observed association between mould and respiratory symptoms.
在一个7岁儿童的人群样本(n = 873)中,评估了父母报告的呼吸道症状、运动后测量的支气管痉挛与家中可见真菌霉菌存在之间的关系。过去一年的喘息是与报告的潮湿尤其是霉菌最密切相关的症状。霉菌与喘息的未调整优势比为3.70(95%置信区间2.22至6.15),在调整住房保有情况、每间房人数、家庭中吸烟者数量和燃气烹饪后,这一结果仍然非常显著(优势比3.00(1.72至5.25))。通过自由跑步6分钟后一秒用力呼气量的减少来验证喘息报告。在所有测量的支气管易激性水平上,来自有霉菌家庭的儿童报告喘息更为常见。有霉菌家庭和无霉菌家庭的儿童在测量的支气管痉挛程度上没有显著差异。对家中潮湿或霉菌的认知可能是父母报告症状的一个决定因素,并且可能解释了观察到的霉菌与呼吸道症状之间的大部分关联。