Hsi E D, Foreman K E, Duggan J, Alkan S, Kauffman C A, Aronow H D, Nickoloff B J
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153-5385, USA.
Am J Surg Pathol. 1998 Apr;22(4):493-9. doi: 10.1097/00000478-199804000-00016.
Body cavity-based lymphoma, also known as primary effusion lymphoma, is a newly recognized acquired immunodeficiency syndrome (AIDS)-related lymphoma that has been linked to the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). To date, direct visualization of the virus in a clinical sample has not been demonstrated. We have performed an extensive clinical, histologic, immunophenotypic, ultrastructural, and molecular genetic correlative study on multiple tissue samples obtained premortem and at autopsy from an patient with AIDS with Kaposi's sarcoma and body cavity-based lymphomas. We demonstrate the presence of human herpesvirus-8 in a primary clinical sample at the ultrastructural and molecular level, as well as document multiple lymphomatous tumor masses at autopsy.
体腔淋巴瘤，也称为原发性渗出性淋巴瘤，是一种新认识的与获得性免疫缺陷综合征（艾滋病）相关的淋巴瘤，它与卡波西肉瘤相关疱疹病毒（KSHV/HHV-8）有关。迄今为止，尚未在临床样本中直接观察到该病毒。我们对一名患有艾滋病、卡波西肉瘤和体腔淋巴瘤的患者生前及尸检时获取的多个组织样本进行了广泛的临床、组织学、免疫表型、超微结构和分子遗传学相关性研究。我们在超微结构和分子水平上证明了原发性临床样本中存在人类疱疹病毒8型，同时在尸检时记录了多个淋巴瘤肿瘤块。
