Contreras G R, Chan-Yeung M
Department of Medicine, University of British Columbia Vancouver, Canada.
Occup Environ Med. 1997 Nov;54(11):836-9. doi: 10.1136/oem.54.11.836.
To study the airway response and its mechanism to welding fumes in six welders with respiratory symptoms.
Methacholine and welding challenge tests were carried out. The concentration of welding fumes during the exposure test was measured. On two subjects who developed bronchoconstricition to welding challenge, additional tests were carried out including prick, patch, and inhalation challenges with metal salt solutions.
Three subjects developed immediate bronchial reaction to exposure to welding fume; one to mild steel and stainless steel welding, another to mild steel and galvanised welding, and one only to galvanised welding. They all had a moderate to pronounced degree of non-specific bronchial hyperresponsiveness. The concentration of fumes during welding tests, particularly to galvanised welding, was high. An inhalation challenge test with zinc chloride salt solution in two subjects who reacted to galvanised welding was negative. Prick and patch tests with zinc chloride were also negative.
The airway response to welding in these subjects is non-specific and is due to irritation rather than to sensitisation.
研究6名有呼吸道症状的焊工对焊接烟尘的气道反应及其机制。
进行了乙酰甲胆碱和焊接激发试验。测量了暴露试验期间焊接烟尘的浓度。对两名对焊接激发试验出现支气管收缩的受试者进行了额外试验，包括用金属盐溶液进行点刺、斑贴和吸入激发试验。
3名受试者在接触焊接烟尘后出现即刻支气管反应；1名对低碳钢和不锈钢焊接有反应，另1名对低碳钢和镀锌焊接有反应，1名仅对镀锌焊接有反应。他们都有中度至明显程度的非特异性支气管高反应性。焊接试验期间，尤其是镀锌焊接时的烟尘浓度很高。在两名对镀锌焊接有反应的受试者中，用氯化锌盐溶液进行的吸入激发试验为阴性。用氯化锌进行的点刺和斑贴试验也为阴性。
这些受试者对焊接的气道反应是非特异性的，是由刺激而非致敏引起的。
