Lindén M
Department of Biomedical Engineering, Linköping University, Sweden.
Med Biol Eng Comput. 1997 Nov;35(6):575-80. doi: 10.1007/BF02510963.
A method is suggested for quantitative flow assessment of whole-blood perfusing tubes with diameters in the range from 500 microns to 1.5 mm, for velocities below 9 mm s-1. The algorithm is based both on the Doppler broadening of backscattered laser light and the magnitude of the diameter of the perfused tube. A bandwidth-modified high-resolution laser Doppler perfusion imaging system is used to record the Doppler broadening. A flow model, consisting of a linearly narrowing tube (inner diameter 620-1330 microns), is connected to a precision infusion pump and perfused by human whole blood of volume flows ranging from 0 to 6.6 mm3 s-1. Empirical data are fitted into a regression model, and the parameters of the algorithm can be determined, resulting in a correlation coefficient of 0.975 between the predicted and true volume flows. Using this algorithm, volume flows in tubes of inner diameters of 500 microns, 750 microns and 1.4 mm are predicted, with accuracies corresponding to correlation coefficients of 0.994, 0.993 and 0.996.
本文提出了一种用于定量评估直径在500微米至1.5毫米范围内、流速低于9毫米/秒的全血灌注管流量的方法。该算法基于后向散射激光的多普勒展宽以及灌注管直径的大小。使用带宽修正的高分辨率激光多普勒灌注成像系统记录多普勒展宽。一个由线性变窄管（内径620 - 1330微米）组成的流动模型连接到精密输液泵，并由体积流量范围为0至6.6立方毫米/秒的人体全血进行灌注。将实验数据拟合到回归模型中，可以确定算法的参数，预测流量与真实流量之间的相关系数为0.975。使用该算法对内径为500微米、750微米和1.4毫米的管子中的体积流量进行预测，其精度对应的相关系数分别为0.994、0.993和0.996。
