Cheek A O, Vonier P M, Oberdörster E, Burow B C, McLachlan J A
Tulane-Xavier Center for Bioenvironmental Research, New Orleans, LA, USA.
Environ Health Perspect. 1998 Feb;106 Suppl 1(Suppl 1):5-10. doi: 10.1289/ehp.106-1533276.
Endogenous and exogenous chemical signals have evolved as a means for organisms to respond to physical or biological stimuli in the environment. Sensitivity to these signals can make organisms vulnerable to inadvertent signals from xenobiotics. In this review we discuss how various chemicals can interact with steroid-like signaling pathways, especially estrogen. Numerous compounds have estrogenic activity, including steroids, phytoestrogens, and synthetic chemicals. We compare bioavailability, metabolism, interaction with receptors, and interaction with cell-signaling pathways among these three structurally diverse groups in order to understand how these chemicals influence physiological responses. Based on their mechanisms of action, chemical steroid mimics could plausibly be associated with recent adverse health trends in humans and animals.
内源性和外源性化学信号已演变成生物体应对环境中物理或生物刺激的一种方式。对这些信号的敏感性会使生物体易受来自异种生物的意外信号影响。在本综述中，我们讨论了各种化学物质如何与类固醇样信号通路相互作用，尤其是雌激素。许多化合物具有雌激素活性，包括类固醇、植物雌激素和合成化学物质。我们比较了这三类结构不同的化合物在生物利用度、代谢、与受体的相互作用以及与细胞信号通路的相互作用，以便了解这些化学物质如何影响生理反应。基于其作用机制，化学类固醇模拟物可能与人类和动物近期的不良健康趋势存在关联。
