Galteau M M, Guyon M, Gueguen R, Siest G
Laboratoire de Biologie Clinique, Centre de Médecine Preventive, Vandoeuvre-Lès-Nancy, France.
Clin Chem Lab Med. 2001 Sep;39(9):850-7. doi: 10.1515/CCLM.2001.141.
Human cystatin C is a low molecular weight protein which has been proposed as a better marker of glomerular filtration rate than creatinine. To be able to interpret results obtained in different patient populations it is necessary to define cystatin C reference values. We measured serum concentration of cystatin C in 1223 subjects using a particle-enhanced nephelometric assay. Subjects were aged 4 to 79 years and were selected among apparently healthy individuals who came to the Centre for Preventive Medicine in Vandoeuvre-Lès-Nancy, France. We observed a Gaussian distribution of cystatin C concentration in serum. We did not find any effect of age or gender in children, hormonal status in women (puberty, menopause, oral contraceptives or hormone replacement therapy) or alcohol intake. Cystatin C concentration was slightly lower in female than in male adults below the age of 60 years. Cystatin C levels significantly increased above the age of 60 in both males and females, probably due to physiological aging of renal function. No other significant differences were observed between males and females. Using multiple regression analysis, moderate correlations were observed between body mass index and cystatin C, and between smoking and cystatin C, but these were not biologically significant. According to the literature, only methylprednisolone and cyclosporin A increased and decreased cystatin C levels, respectively. The reference values for cystatin C obtained in a carefully selected population were 0.75+/-0.089 mg/l for children aged 4-19 years, 0.74+/-0.100 mg/l for males and 0.65+/-0.085 mg/l for females (aged 20-59 years), and 0.83+/-0.103 mg/l for older individuals (> or =60 years).
人胱抑素C是一种低分子量蛋白质，有人提出它是比肌酐更好的肾小球滤过率标志物。为了能够解读在不同患者群体中获得的结果，有必要确定胱抑素C的参考值。我们使用颗粒增强散射比浊法测量了1223名受试者的血清胱抑素C浓度。受试者年龄在4至79岁之间，选自法国南锡万多厄夫勒预防医学中心的表面健康个体。我们观察到血清中胱抑素C浓度呈高斯分布。我们未发现年龄或性别对儿童有任何影响，女性的激素状态（青春期、更年期、口服避孕药或激素替代疗法）或酒精摄入量也无影响。60岁以下成年女性的胱抑素C浓度略低于成年男性。60岁以上男性和女性的胱抑素C水平均显著升高，这可能是由于肾功能的生理性老化。男性和女性之间未观察到其他显著差异。使用多元回归分析，观察到体重指数与胱抑素C之间以及吸烟与胱抑素C之间存在中度相关性，但这些在生物学上并不显著。根据文献，只有甲泼尼龙和环孢素A分别升高和降低了胱抑素C水平。在精心挑选的人群中获得的胱抑素C参考值为：4至19岁儿童为0.75±0.089mg/l，20至59岁男性为0.74±0.100mg/l，女性为0.65±0.085mg/l，60岁及以上老年人为0.83±0.103mg/l。
