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HIV-inhibitory and cytotoxic oligostilbenes from the leaves of Hopea malibato.

作者信息

Dai J R, Hallock Y F, Cardellina J H, Boyd M R

机构信息

Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.

出版信息

J Nat Prod. 1998 Mar;61(3):351-3. doi: 10.1021/np970519h.

DOI:10.1021/np970519h
PMID:9544565
Abstract

Three new oligostilbenes, malibatols A (1) and B (2) and dibalanocarpol (3), together with one known oligostilbene balanocarpol (4), were isolated from the organic extract of the leaves of Hopea malibato. The structure elucidation of these compounds was based on the interpretation of their chemical and spectral data. Compounds 3 and 4 exhibited very modest HIV-inhibitory activity, while compounds 1 and 2 were cytotoxic to the host cells (CEM SS) in the antiviral assay.

摘要

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