从植物、海洋生物和微生物中分离并鉴定新型抗艾滋病毒及细胞毒性先导化合物。
Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.
作者信息
McKee T C, Bokesch H R, McCormick J L, Rashid M A, Spielvogel D, Gustafson K R, Alavanja M M, Cardelline J H, Boyd M R
机构信息
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
出版信息
J Nat Prod. 1997 May;60(5):431-8. doi: 10.1021/np970031g.
New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fiber assay.
新的细胞毒性异马拉巴烷三萜已从一种海绵（Stelletta sp.）中分离出来（1 - 7）；从刺桐属的两种热带植物中阐明了抗HIV紫檀烷（8和9）和异黄酮（12 - 16和18）；并且从镰刀菌属和链格孢属的真菌中鉴定出了抗HIV恩镰孢菌素（20和22 - 23）。在中空纤维试验中评估了恩镰孢菌素的体内抗HIV活性。
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