Wagner B K, Zavotsky K E, Sweeney J B, Palmeri B A, Hammond J S
Department of Pharmacy Practice, College of Pharmacy, Rutgers University, Piscataway, New Jersey, USA.
Pharmacotherapy. 1998 Mar-Apr;18(2):358-63.
To investigate patient recall of therapeutic paralysis (TP) in a surgical critical care unit.
Prospectively applied structured interview of patients undergoing TP over 18 months.
Surgical critical care unit with 27 beds at a tertiary care university teaching hospital.
Forty patients admitted for postoperative care after coronary artery bypass graft surgery, trauma, or gastrointestinal surgery.
Patients received TP and concurrent sedation with benzodiazepines, propofol, and narcotics.
After the end of TP patients were asked to recall the experience, and their responses were ranked on a four-point ordinal scale. Four of 11 patients recalled mostly negative events and experiences with TP, such as sleeplessness, discomfort, pain, anxiety, and inconsistent caregiver communication. All patients with recall experienced fear, anxiety, and sleeplessness. Single-drug therapy with propofol and inadequate benzodiazepine dosing were linked to patient recall.
Patient recollection from TP may be more common than appreciated and is generally unpleasant. Adequate dosing with benzodiazepines and narcotics is warranted to prevent recall and discomfort.
调查外科重症监护病房患者对治疗性麻痹(TP)的回忆情况。
对接受TP治疗超过18个月的患者进行前瞻性应用的结构化访谈。
一所三级护理大学教学医院的拥有27张床位的外科重症监护病房。
40例因冠状动脉搭桥手术、创伤或胃肠手术后接受术后护理的患者。
患者接受TP治疗并同时使用苯二氮卓类药物、丙泊酚和麻醉剂进行镇静。
TP结束后,要求患者回忆这段经历,并根据四点有序量表对他们的回答进行评分。11名患者中有4名主要回忆起与TP相关的负面事件和经历,如失眠、不适、疼痛、焦虑以及护理人员沟通不一致。所有有回忆的患者都经历了恐惧、焦虑和失眠。丙泊酚单药治疗和苯二氮卓类药物剂量不足与患者回忆有关。
患者对TP的回忆可能比预期更常见,且总体上令人不愉快。有必要给予足够剂量的苯二氮卓类药物和麻醉剂以防止回忆和不适。