Molez J F
Laboratoire de Paludologie, Institut Francais de Recherche Scientifique pour le Developpement en Cooperation (ORSTOM), Dakar, Senegal.
Am J Trop Med Hyg. 1998 Mar;58(3):273-6. doi: 10.4269/ajtmh.1998.58.273.
In Europe before the advent of the acquired immunodeficiency syndrome (AIDS), fatal cases of infection with Cryptococcus neoformans resembling acute meningitis were rarely described and never in young adults. However, rapidly fatal cryptococcal meningitis in young Africans has been known to exist in central Africa for at least 30 years, mainly in the lower area of the Congo River basin. Cases have been reported in this area since 1953, particularly in young patients during the 1950s. It is also known that central African AIDS patients frequently suffer from cryptococcosis, and there is a possibility that earlier clinical reports of encephalitis were actually fatal cases of AIDS in young Africans. It appears possible that the central part of the African continent is the area where human immunodeficiency virus originated.
在获得性免疫缺陷综合征（艾滋病）出现之前的欧洲，很少有关于新型隐球菌感染导致类似急性脑膜炎的致命病例的描述，且从未在年轻成年人中出现过。然而，在非洲中部，至少30年来一直存在年轻非洲人迅速死于隐球菌性脑膜炎的情况，主要发生在刚果河流域下游地区。自1953年以来，该地区已有病例报告，尤其是在20世纪50年代的年轻患者中。还已知非洲中部的艾滋病患者经常患有隐球菌病，而且早期关于脑炎的临床报告有可能实际上是年轻非洲人艾滋病的致命病例。看来非洲大陆中部地区有可能是人类免疫缺陷病毒的起源地。
