[使用茶碱者维生素B6水平低于正常]

[Subnormal vitamin B6 levels in theophylline users].

作者信息

Martinez de Haas M G, Poels P J, de Weert C J, Thomas C M, Rooyackers J M, Hoefnagels W H

机构信息

Afd. Geriatrie, Academisch Ziekenhuis, Nijmegen.

出版信息

Ned Tijdschr Geneeskd. 1997 Nov 8;141(45):2176-9.

PMID:9550799

Abstract

OBJECTIVE

To study the effect of theophylline use on the vitamin B-6 status.

DESIGN

Descriptive.

SETTING

Department of Geriatric Medicine of Nijmegen Academic Hospital and Department of Pulmonary Diseases, University of Nijmegen, the Netherlands.

PATIENTS AND METHODS

Vitamin B-6 status was determined by measuring pyridoxal-5'-phosphate (PLP) in whole blood (using a high performance liquid chromatography method, reference values: 35-107 mumol/l) in 141 patients from the Geriatric department (84 non-chronic obstructive pulmonary disease (COPD), 40 COPD patients without theophylline and 17 COPD patients with theophylline) and in 25 non-geriatric COPD patients on theophylline.

RESULTS

Of the 84 geriatric non-COPD patients (mean age: 82 years; SD: 6) 56% had a subnormal vitamin B-6 status, of the 40 geriatric COPD patients without theophylline (82 years; SD: 6) 70%, of the 17 geriatric COPD patients on theophylline (80 years; SD: 5) 94% and of the 25 non-geriatric COPD patients on theophylline (62 years; SD: 11) 96%.

CONCLUSION

In patients who used theophylline a higher prevalence of subnormal vitamin B-6 status was found than in patients who did not.

摘要

目的

研究使用茶碱对维生素B-6状态的影响。

设计

描述性研究。

地点

荷兰奈梅亨学术医院老年医学科和奈梅亨大学肺病科。

患者和方法

通过测定141例老年科患者（84例非慢性阻塞性肺疾病（COPD）患者、40例未使用茶碱的COPD患者和17例使用茶碱的COPD患者）以及25例使用茶碱的非老年COPD患者全血中的磷酸吡哆醛（PLP）（采用高效液相色谱法，参考值：35 - 107μmol/L）来确定维生素B-6状态。

结果

84例老年非COPD患者（平均年龄：82岁；标准差：6）中，56%的患者维生素B-6状态低于正常；40例未使用茶碱的老年COPD患者（82岁；标准差：6）中，70%低于正常；17例使用茶碱的老年COPD患者（80岁；标准差：5）中，94%低于正常；25例使用茶碱的非老年COPD患者（62岁；标准差：11）中，96%低于正常。