Moreno F J, Santoyo J, Bondía J A, Suárez M A, Jiménez M, Fernández J L, Conde M, Marín R, Ribeiro M, Peláez J M, de la Fuente A
Servicio de Cirugía General y Digestiva, Hospital Regional Carlos Haya, Málaga.
Rev Esp Enferm Dig. 1998 Jan;90(1):48-50.
The molecular basis of porphyria cutanea tarda is defective activity of hepatic uroporphyrinogen decarboxylase. A common characteristic is liver dysfunction than goes from cirrhosis to hepatocellular carcinoma. A high prevalence of hepatitis C virus markers has been demonstrated. We study a patient with PCT and hepatitis C virus markers that finally develops to hepatocellular carcinoma without previous cirrhosis. Previous studies with association of PCT and hepatitis C virus markers, have found liver diseases ranging from cirrhosis to hepatocellular carcinoma. The importance of this study is the absence of cirrhosis.
迟发性皮肤卟啉症的分子基础是肝脏尿卟啉原脱羧酶活性缺陷。一个常见特征是肝功能障碍，可发展为肝硬化乃至肝细胞癌。丙型肝炎病毒标志物的高流行率已得到证实。我们研究了一名患有迟发性皮肤卟啉症且有丙型肝炎病毒标志物的患者，该患者最终发展为肝细胞癌，之前并无肝硬化。先前关于迟发性皮肤卟啉症与丙型肝炎病毒标志物关联的研究发现，肝脏疾病范围从肝硬化到肝细胞癌。本研究的重要之处在于不存在肝硬化。
