Radkowski M, Stańczak W, Walewska-Zielecka B, Loch T, Cianciara J, Wang L F, Laskus T
Institute of Infectious Diseases, Warsaw, Poland.
Infection. 1998 Mar-Apr;26(2):113-5. doi: 10.1007/BF02767771.
This study evaluated the epidemiology and impact of hepatitis G virus (HGV) infection in patients with chronic hepatitis B and C. Serum samples were obtained from 128 consecutive untreated patients with chronic hepatitis B (72 cases) or C (56 cases). The presence of HGV RNA was determined by PCR amplification of the 5'untranslated region; the sensitivity of the assays was ten template copy equivalents. The prevalence of HGV RNA in hepatitis B and C was found to be 25% and 34%, respectively. HGV-positive and HGV-negative patients did not differ with respect to risk factors for infection, age, sex, or alanine aminotransferase activity. Similarly, there was no difference in the severity of liver disease, as assessed with HAI score. In conclusion, we found a very high prevalence of HGV infection in chronic hepatitis B and C patients in Poland. Nevertheless, no evidence was found that HGV coinfection has any impact on the severity of the underlying disease.
本研究评估了庚型肝炎病毒（HGV）感染在慢性乙型和丙型肝炎患者中的流行病学及影响。从128例连续的未经治疗的慢性乙型肝炎患者（72例）或丙型肝炎患者（56例）中获取血清样本。通过对5'非翻译区进行PCR扩增来确定HGV RNA的存在；检测的灵敏度为十个模板拷贝当量。发现乙型肝炎和丙型肝炎中HGV RNA的流行率分别为25%和34%。HGV阳性和HGV阴性患者在感染危险因素、年龄、性别或丙氨酸氨基转移酶活性方面无差异。同样，用HAI评分评估时，肝病严重程度也无差异。总之，我们发现波兰慢性乙型和丙型肝炎患者中HGV感染的流行率非常高。然而，未发现证据表明HGV合并感染对基础疾病的严重程度有任何影响。
