Narawane N M, Bhatia S J, Mistry F P, Abraham P, Dherai A J
Department of Gastroenterology, K E M Hospital, Mumbai.
Indian J Gastroenterol. 1998 Apr;17(2):55-7.
The normal esophagus has not been manometrically mapped. The transition zone between esophageal smooth and skeletal muscles has also not been defined manometrically.
To manometrically map the normal esophagus and to define the transition zone.
Thirty normal adults [23 men; mean age 34.8 (10.4) years] underwent manometry using a water-perfused system. The lower esophageal sphincter (LES) was studied by station pull-through, and esophageal body musculature was evaluated at 1-cm intervals with five wet swallows at each level. The transition zone was identified as an area where the wave-forms did not resemble typical skeletal or smooth muscle wave-forms.
The basal mid-expiratory LES pressure was 18.7 (7.2) mmHg, and its length was 3.6 (1.2) cm. Based on our findings, we defined the transition zone as an area where either the amplitude of contraction was < 40 mmHg or, if the amplitude was 40-50 mmHg, the rate of change of pressure from baseline to peak of the wave was < 50 mmHg/s. The lengths of the skeletal, transition and smooth muscle zones were 2.8 (1.2), 4.0 (1.7) and 12.5 (2.7) cm, respectively. The amplitude and dp/dt of contraction and transmission velocity were lowest in the transition zone (p < 0.05).
We have manometrically mapped the normal esophageal muscle zones; the parameters obtained may be used as reference values. The manometric criteria for the transition zone have also been defined.
正常食管尚未进行测压图谱绘制。食管平滑肌与骨骼肌之间的过渡区也未通过测压来界定。
对正常食管进行测压图谱绘制并界定过渡区。
30名正常成年人（23名男性；平均年龄34.8[10.4]岁）使用水灌注系统进行测压。通过逐点牵拉法研究食管下括约肌（LES），并以1厘米间隔对食管体部肌肉组织进行评估，每个水平进行5次湿咽试验。过渡区被确定为波形与典型骨骼肌或平滑肌波形不同的区域。
呼气中期LES基础压力为18.7（7.2）mmHg，其长度为3.6（1.2）厘米。基于我们的研究结果，我们将过渡区定义为收缩幅度<40 mmHg的区域，或者如果幅度为40 - 50 mmHg，则从基线到波峰的压力变化率<50 mmHg/s的区域。骨骼肌区、过渡区和平滑肌区的长度分别为2.8（1.2）厘米、4.0（1.7）厘米和12.5（2.7）厘米。过渡区的收缩幅度、dp/dt和传导速度最低（p<0.05）。
我们已对正常食管肌肉区域进行了测压图谱绘制；所获得的参数可作为参考值。还定义了过渡区的测压标准。
