Peghini P L, Pursnani K G, Gideon M R, Castell J A, Nierman J, Castell D O
Department of Medicine, Allegheny University Hospitals-Graduate, Philadelphia, Pennsylvania 19146, USA.
Am J Physiol. 1998 Feb;274(2):G325-30. doi: 10.1152/ajpgi.1998.274.2.G325.
The human esophagus is composed of striated muscle proximally and of smooth muscle distally with a transition zone between the two. Striated muscle contracts much faster than smooth muscle. The change in pressure over time (dP/dt) of the contraction amplitude should therefore be higher in proximal than in distal esophagus, reflecting the presence of striated muscle proximally. There were 34 normal esophageal manometries of patients analyzed for swallow amplitude and dP/dt in the pharynx and esophagus. An additional 11 healthy controls were similarly studied. Amplitudes in pharynx and proximal and distal esophagus were not different. The mid-esophagus had a pressure trough (P < 0.001). The dP/dt in the pharynx was much higher than that in the esophagus (P < 0.001). The dP/dt of proximal and distal esophagus were of the same order of magnitude. The manometric behavior of the striated muscle portion of the proximal esophagus differs from that seen in the pharynx and shows similar characteristics to distal esophageal smooth muscle.
人类食管近端由横纹肌组成，远端由平滑肌组成，两者之间有一个过渡区。横纹肌的收缩速度比平滑肌快得多。因此，近端食管收缩幅度随时间的压力变化率（dP/dt）应高于远端食管，这反映了近端存在横纹肌。对34例患者的正常食管测压进行分析，测量其吞咽幅度以及咽部和食管的dP/dt。另外对11名健康对照者进行了类似研究。咽部、食管近端和远端的幅度没有差异。食管中部有一个压力谷（P < 0.001）。咽部的dP/dt远高于食管（P < 0.001）。食管近端和远端的dP/dt处于同一数量级。食管近端横纹肌部分的测压行为与咽部不同，与远端食管平滑肌表现出相似特征。
