Divatia J V, Jacques T, Day P, Bihari D J
Intensive Care Unit, St George Hospital, Sydney, N.S.W.
Anaesth Intensive Care. 1998 Apr;26(2):184-8. doi: 10.1177/0310057X9802600209.
In critically ill patients, serial measurements of blood lactate may indicate adequacy of therapy and predict development of multi-organ failure. We studied the accuracy, precision, and repeatability of the newly developed 800 Series Lactate Sensor (Ciba Corning Diagnostic Corp., Medfield, U.S.A.). Lactate levels determined with the sensor were compared with the standard laboratory method (Abbott TDX) in 75 paired arterial blood samples from 20 patients. Agreement between methods was determined and the mean coefficient of variation calculated for repeated measurements. The bias of the sensor was -0.38 mmol/l (CI -0.23 to -0.53), and the precision +/- 0.67. The coefficient of variation for repeated measurements was 1.95% with the sensor, and 11.5% with the TDX (P = 0.007). The new sensor offers a more reproducible, rapid method of measuring lactate, vital for serial measurements. The relatively wide limits of agreement between the methods reflect the greater variability of the TDX assay.
在重症患者中，连续测量血乳酸水平可指示治疗的充分性，并预测多器官功能衰竭的发生。我们研究了新开发的800系列乳酸传感器（美国马萨诸塞州米德菲尔德市的汽巴康宁诊断公司）的准确性、精密度和可重复性。将该传感器测定的乳酸水平与标准实验室方法（雅培TDX）在来自20例患者的75对动脉血样本中进行比较。确定了两种方法之间的一致性，并计算了重复测量的平均变异系数。该传感器的偏差为-0.38 mmol/L（95%可信区间为-0.23至-0.53），精密度为±0.67。使用该传感器重复测量的变异系数为1.95%，而使用TDX为11.5%（P = 0.007）。这种新型传感器提供了一种更可重复、快速的测量乳酸的方法，这对于连续测量至关重要。两种方法之间相对较宽的一致性界限反映了TDX测定法的变异性更大。
