Adlouni A, Ghalim N, Saïle R, Hda N, Parra H J, Benslimane A
Département de Biologie, Faculté des Sciences Ben M'sik, Casablanca, Maroc.
Clin Chim Acta. 1998 Mar 23;271(2):179-89. doi: 10.1016/s0009-8981(97)00245-3.
In order to investigate for the first time in Morocco the effect of fasting in Ramadan, the ninth lunar month of the muslim year, on lipoprotein metabolism, we determined the levels of serum apolipoproteins; apolipoprotein AI (apo AI), apo B, apo AIV and those of lipoprotein particles; apo AI-containing lipoprotein particles (Lp AI) and also apo AI and apo AII containing lipoprotein particles (Lp AI:AII) in a group of 32 healthy, volunteer adult males. Determination of all these parameters was carried out on each week of the month of Ramadan and the results are compared with the pre-fasting and the post-fasting values. Ramadan fasting reduces significantly serum apo B (P < 0.05), while serum apo AI is significantly increased (P < 0.05) compared with the pre-fasting period. The increase of apo AI occurred on day 29 of Ramadan by 11.8%. Serum apo AIV was unchanged during the fasting period indicating that food intake during Ramadan is not based on lipid diet. The observed diet pattern during Ramadan showed an increase of total energy intake based on carbohydrates (+1.4% of total energy), proteins (+0.4% of total energy) but not on fat (-0.7% of total energy), compared with a usual diet used in the rest of the year. The fat diet is high in monounsaturated (P < 0.05) and polyunsaturated fatty acid in contrast to saturated fatty acid which decreased (P < 0.05) during Ramadan. On the other hand, analysis of serum Lp AI and Lp AI:AII showed that the levels of Lp AI:AII were unchanged but those of Lp AI were significantly increased (P < 0.01) at the end of Ramadan. These findings show that feeding behaviour that occurs during Ramadan beneficially affects serum apolipoprotein metabolism and may contribute to prevention of cardiovascular diseases.
为了首次在摩洛哥研究伊斯兰教历第九个月斋月禁食对脂蛋白代谢的影响，我们测定了32名健康成年男性志愿者血清载脂蛋白水平，即载脂蛋白AI（apo AI）、apo B、apo AIV，以及脂蛋白颗粒水平，含apo AI的脂蛋白颗粒（Lp AI）和含apo AI及apo AII的脂蛋白颗粒（Lp AI:AII）。在斋月的每个星期对所有这些参数进行测定，并将结果与禁食前和禁食后的数值进行比较。与禁食前相比，斋月禁食显著降低血清apo B（P < 0.05），而血清apo AI显著升高（P < 0.05）。在斋月第29天，apo AI升高了11.8%。禁食期间血清apo AIV未发生变化，这表明斋月期间的食物摄入并非基于脂质饮食。与一年中其他时间的常规饮食相比，斋月期间观察到的饮食模式显示，基于碳水化合物的总能量摄入量增加（占总能量的1.4%）、蛋白质增加（占总能量的0.4%），但脂肪减少（占总能量的 -0.7%）。斋月期间脂肪饮食中，单不饱和脂肪酸（P < 0.05）和多不饱和脂肪酸含量较高，而饱和脂肪酸含量下降（P < 0.05）。另一方面，血清Lp AI和Lp AI:AII分析显示，斋月结束时Lp AI:AII水平未变，但Lp AI水平显著升高（P < 0.01）。这些发现表明，斋月期间的进食行为对血清载脂蛋白代谢有有益影响，可能有助于预防心血管疾病。
