Arumugam N, Sivakumar V, Thanislass J, Devaraj H
Department of Zoology, University of Madras, Chennai, India.
Indian J Exp Biol. 1997 Dec;35(12):1373-4.
Effect of acrolein (2.5 mg/kg body wt/day) on the rat liver antioxidant defense system was investigated. Following 45 days of acrolein exposure, the levels of glutathione, ascorbic acid and the activity of catalase were decreased whereas the activities of superoxide dismutase and glutathione peroxidase were increased. The increase in the level of thiobarbituric acid reactive substances in the acrolein treated rats showed oxidative damage. The results indicate that acrolein interferes with the antioxidant defense system of rat liver.
研究了丙烯醛（2.5毫克/千克体重/天）对大鼠肝脏抗氧化防御系统的影响。丙烯醛暴露45天后，谷胱甘肽、抗坏血酸水平和过氧化氢酶活性降低，而超氧化物歧化酶和谷胱甘肽过氧化物酶活性增加。丙烯醛处理的大鼠中硫代巴比妥酸反应性物质水平的升高表明存在氧化损伤。结果表明，丙烯醛会干扰大鼠肝脏的抗氧化防御系统。
